We have studied the regional and subcellular distribution, functional role, and pharmacology of quinoid dihydropterin reductase (QDPR) and endogenous reduced pterins (PH4) subserving tyrosin hydroxylase (TOH) and tryptophan hydroxylase in the rat brain. There is a significant correlation between the regional distribution of PH4 and TOH but not between PH4 and tryptophan hydroxylase or between e...

A triptycene-based bis(benzoxazole) diacid ligand H(2)L2(Ph4) bearing sterically encumbering groups was synthesized. Treatment of H(2)L2(Ph4) with Fe(OTf)(3) afforded a C(2)-symmetric trinuclear iron(III) complex, [NaFe(3)(L2(Ph4))(2)(μ(3)-O)(μ-O(2)CCPh(3))(2)(H(2)O)(3)](OTf)(2) (8). The triiron core of this complex adopts the well known "basic iron acetate" structure where the heteroleptic car...

The stability of 10 active pharmaceutical ingredients was studied in SyrSpend SF PH4 or SyrSpend SF Alka at room and/or refrigerated temperature (2°C to 8°C). An oral suspension of each active pharmaceutical ingredient was compounded in low actinic plastic bottles at a specific concentration in SyrSpend SF PH4 or SyrSpend SF Alka. Samples were assessed for stability immediately after preparatio...

The present study aimed to evaluate possible variations in the chemical composition and antimicrobial activity of essential oils extracted from Piper marginatum leaves obtained by hydrodistillation at pH4, pH7, pH10. When compared, profiles three were different. A reduction major phenylpropanoids Z-asarone, dillapiole, E-asarone was observed for samples pH4-EO pH10-EO as compared sample pH7- EO...

Phenylalanine hydroxylase (PAH) is the key enzyme in the catabolism of L-Phe. The natural cofactor of PAH, 6R-tetrahydrobiopterin (BH4), negatively regulates the enzyme activity in addition to being an essential cosubstrate for catalysis. The analogue 6-methyltetrahydropterin (6M-PH4) is effective in catalysis but does not regulate PAH. Here, the thermodynamics of binding of BH4 and 6M-PH4 to h...

The Petunia hybrida genes ANTHOCYANIN1 (AN1) and AN2 encode transcription factors with a basic-helix-loop-helix (BHLH) and a MYB domain, respectively, that are required for anthocyanin synthesis and acidification of the vacuole in petal cells. Mutation of PH4 results in a bluer flower color, increased pH of petal extracts, and, in certain genetic backgrounds, the disappearance of anthocyanins a...

The pH control in different cell compartments is essential for the trafficking of vesicles, proteins and small molecules. Vacuolar type H + -ATPases (v-ATPases) and pyrophosphatases (PPases) in plants control the pH of endomembranes compartments whereas P-type H + -ATPases control the pH of the cytosol by pumping protons across the plasma membrane. In this way an electrochemical gradient is cre...

目的：分析阴离子交换层析处理对静注人免疫球蛋白（pH4）制品的影响效果。方法：研究时间：2020.2~2021.2，选择六种批次的静注人免疫球蛋白（pH4），其中三批次采取低温乙醇蛋白分离法（A方法）、其余三批次采用不低温乙醇蛋白分离法联合阴离子交换层析处理（B方法），分析不同方法处理后静注人免疫球蛋白（pH4）制品的相关指标。结果：B方法处理后的静注人免疫球蛋白（pH4）制品IgA水平小于A方法，有统计学意义（P < 0.05）；A方法与B方法处理后的静注人免疫球蛋白（pH4）制品质量相关指标差异无统计学意义（P > 0.05）。结论：阴离子交换层析处理对静注人免疫球蛋白（pH4）制品后，可促进制品整体质量的提高，为临床的安全使用创造有利条件。

A pathological complete response (pCR) after neoadjuvant chemotherapy is observed in approximately 20% of breast cancer patients. A proteomic analysis was performed on plasma and tumor tissue before treatment to evaluate its potential impact on the prediction of response. One hundred and forty-nine breast cancer patients eligible for neoadjuvant c...